Continuous Genomic Intelligence

Millions of datapoints.
The few signals that matter.

Rewise Health is the precision-health intelligence platform for companies. We read genomes, blood, wearables and lifestyle together — continuously — and ship the results as APIs, white-label reports and turnkey programs your members experience under your brand. Calibrated for Indian biology.

3.5B+Proprietary longitudinal datapoints
75+ sourcesEvidence metadatabase
Data-agnosticAny lab · any wearable · any EHR
API & white-labelBuilt B2B-first

01 — The problem

Healthcare generates data.
Very little intelligence.

Genetic testsA static report, read once, filed away. The genome never changes — but what it means for you changes with every blood draw.READ ONCE · NEVER REVISITED
Blood panelsA snapshot of one morning, interpreted against population reference ranges — averages drawn mostly from other populations.SNAPSHOT · NO CONTEXT
WearablesTerabytes of heart rate, sleep and strain — streamed without the biological context that would make any of it actionable.VOLUME · NO MEANING
SymptomsThe signal medicine actually waits for. By the time it appears, the underlying biology has been drifting for years.TOO LATE

Each stream is collected in isolation, read in isolation, and acted on in isolation. The signal that matters lives in the intersection — and no one is reading it.

15 yrs
gap between lifespan and healthspan, globally
3 mo
spent in poor health for every year of life gained

02 — The platform

One intelligence layer between raw biology and your product.

The genome is the constant; everything else is the stream. Rewise ingests both, harmonises them, and runs them through population-calibrated models that surface what is relevant — per person, per use case, continuously.

Data layerIngest · harmonise · de-identify
Genome & PRSEpigenetics115-marker blood panelsMicrobiomeWearablesLifestyle & symptomsEHR

Data-agnostic by design. Any accredited lab, any wearable, any record system. Structured, harmonised and de-identified on ingestion.

Rewise intelligence layerContinuous genomic intelligence
Polygenic risk engine — Indian-cohort calibratedDeep ageing clocksBiomarker reasoning engineKnowledge graph · 75+ sourcesIntervention & protocol engine

Millions of datapoints in; ranked, explainable signals out. Every signal traces to a named pathway — mTOR, SIRT1, NF-κB, PER2 — never a black box. Models normalised on 3.5 billion+ annotated, longitudinal datapoints from a proprietary Indian cohort.

Your productAPI · white-label · reports · app
Signals APIWhite-label intelligence reportsProvider portalMember app modulesProgramme protocols

You ship the experience your members already trust — now powered by genomic intelligence. No genomics team, no model risk, no cohort problem.

03 — The software

Less pitch. More product.

Excerpts from live One.Age report and dashboard surfaces. Partners see the full platform on a demo — this is the shape of what your members receive.

ONE.AGE | PREVENT · BIOLOGICAL AGEEXCERPT
43.7
Bio age
−5.3 yrs vs chronological
8 assessments · 4.7 years · ageing rate 0.89/yr

Trajectory · 4.7 years

Teal: biological · dashed: chronological — the gap is the product.

ONE.AGE | PREVENT · BLOOD PANEL5 OF 115 MARKERS
Folate0.82 ng/mLPRIORITY
Vitamin E8.98 µg/mLLOW
hs-CRP0.6 mg/LOPTIMAL
ApoB▮▮▮ mg/dLFLAGGED
Lp(a)▮▮ nmol/LOPTIMAL

Panel verdict

105 of 115 optimal · 10 flagged · 5 improving since last draw. Each marker cross-read against genotype before a protocol is issued.

MEMBER DASHBOARD · AGEING ARCHITECTUREEXCERPT
Brain
78
Cardiac
65
Metabolic
58
Respiratory
84
Immune
▮▮

Ranked priorities

Every system age links to its drivers, its pathway, and this quarter's protocol — inside your app or ours.

SIGNALS API · v1LIVE SHAPE
// POST /v1/signals
{ "member": "mb_4xk…", "inputs": ["genome", "panel_115", "wearable"] }

// 200 — ranked, explainable
{ "signals": [
  { "id": "methylation.folate", "rank": 1,
    "evidence": ["MTHFR C677T het", "folate 0.82"],
    "protocol": "methylfolate 800–1000 µg/d",
    "retest_days": 90 }, 

04 — The reasoning

The signal is different for every person.
The reasoning never is.

Biological age headlines one report; recovery capacity another; a hormonal transition a third; a disease that hasn't happened yet, the fourth. Rewise doesn't hand back a generic report — it ranks what matters for this individual and traces every conclusion from genome to intervention to a measurable outcome.

One reasoning chain, end to end

ELITE DISTANCE RUNNER · F · 27 · VO₂ PLATEAUED 9 WEEKS
Genome
VO₂max trainability — 91st percentile
PPARGC1A C/C · ACE I/I
Blood
Iron deficit gating the aerobic engine
Ferritin 18 ng/mL · Hb 11.8
Consequence
Ceiling locked — VO₂ stalled below genetic potential
58.4 now · 66–68 ceiling
Intervention
Ferrous bisglycinate 50mg alt-days + vitamin C
Retest week 8
Outcome
Ferritin 18 → 70 · +4–6 ml/kg/min projected
12-week window
Executive · M · 49 · One.Age | Prevent−5.3 YRS
43.7
Bio age
Ageing 0.89 yrs per calendar year
Tracked across 8 assessments · 4.7 years · chronological 49
Blood panel
105/115
Folate
0.82 ↑2.7
Vitamin E
8.98 ↑500
Inflammaging
−0.85 yrs

For him, the ranked signal is methylation: MTHFR C677T plus folate at 0.82 ng/mL. Protocol issued — methylfolate 800–1,000µg daily — retest in 90 days. Biological age is the scoreboard, not the story.

Athlete · F · 27 · Performance intelligenceOVERREACH
58
Readiness
Performance age 23 — 4 yrs younger
Composite of HRV, RHR drift, sleep, hs-CRP · −13 pts in 28 days
VO₂ vs ceiling
58.4/66+
Ferritin
18 ↑70
Omega-3 index
3.6 ↑8.0
HRV 28-day
72→58 ms

Same engine, entirely different signal set. For her, biological age is irrelevant — recovery and the iron gate are the levers. The genome says 2:38–2:42 marathon; the bloodwork says close the iron gate first.

Founder · F · 44 · Hormonal intelligencePERI-TRANSITION
62
Hormonal
Perimenopause signature — ~18 months before symptoms get flagged
FSH trend + estradiol variability + sleep architecture, read together
FSH trend
28 ↗
E2 variability
±42%
TSH
4.2
Vitamin D
19 ↑50

Single hormone tests look “normal” — the signal is variability over time crossed with a slow-COMT estrogen-metabolism genotype and rising bone-turnover risk. Protocol: strength training 3×/wk, vitamin D repletion, quarterly hormone cadence, clinician consult — years before standard care reacts.

Product lead · M · 31 · Metabolic preventionT2D PRS 87TH
5.6
HbA1c %
“Normal” today — trajectory says prediabetic by 34
87th-percentile T2D genetics · every marker in range, all drifting
T2D PRS
87th pctl
Fasting insulin
14 ↗
TG : HDL
3.4
HbA1c slope
+0.1/yr

For him the signal is the slope, not the level — Indian biology runs a decade ahead of the reference ranges. Protocol: resistance training, fibre-first meal sequencing, 120-day retest. Standard care intervenes at 6.5%; the genome said start at 31.

05 — Intelligence domains

One engine. Every major system.

Partners license the domains their members need. Each runs on the same reasoning layer — genome, blood and lifestyle read together, traced to mechanism.

Featured domain

Hormonal Intelligence

Women's health is decided by hormones read against genetics and time — and it is the most underserved intelligence problem in health today. Reference ranges built on male cohorts miss it; Rewise reads it natively, across every life stage.

PerimenopauseMenopausePCOSThyroidStress axisFemale metabolic healthBone & muscle

For women's-health platforms ready to own the category.

Domain

Metabolic

Insulin sensitivity, weight response, diabetes risk — a decade earlier in Indians, read a decade earlier here.

ObesityT2D riskInsulin
Domain

Cardiovascular

Lipids, inflammation and pressure traced to genotype — ApoB and Lp(a) behaviour the panels alone can't explain.

LipidsInflammationBP
Domain

Fitness & Performance

Trainability ceilings, recovery capacity, injury susceptibility — the athlete chain above, productised.

VO₂ ceilingRecoveryInjury risk
Domain

Nutrition

Micronutrient status, food response and supplement protocols grounded in nutrigenomics, not quizzes.

MicronutrientsFood responseSupplements
Domain

Gut & Microbiome

Microbiome composition read against diet, genotype and inflammation — the gut as a driver, not a buzzword.

Gut diversityDysbiosisFood–gut response
Domain

Healthy Ageing

Biological age, system ages and ageing-pathway signals — the scoreboard for everything above.

Biological ageSystem agesLongevity

04 — Why population matters

Polygenic risk scores calibrated for Indian and South Asian populations.

Most genomic models are trained on European-ancestry cohorts and quietly lose accuracy on Indian genomes. Reference ranges, risk thresholds, ageing clocks — all drawn from someone else's biology. Rewise was built the other way around: population-specific first, data-agnostic and globally scalable second.

~10 yrsearlier onset of cardiometabolic disease in Indian populations — diabetes and heart disease arrive a decade ahead of Western reference cohorts.
<2%of global GWAS data represents Indian-ancestry genomes, while India alone is home to over a sixth of humanity. Generic PRS inherit that blind spot.
2,000+ethnic groups across India. Body composition, lipid behaviour and ageing patterns differ enough that imported models misclassify risk.

The Rewise answer

3.5B+ · datapoints

Every ageing clock and polygenic risk score is normalised against 3.5 billion+ annotated, longitudinal datapoints from a proprietary Indian cohort — restoring the sensitivity and specificity that imported models lose. Genomic analysis finally reading the right population.

Cohort composition and scale are disclosed under NDA. The architecture stays data-agnostic — the same calibration discipline extends to any population as partner data grows.

07 — Outcomes

What partners actually buy.

Not technology — results. Each partner type integrates Rewise for one commercial reason. Here it is, plainly.

Diagnostic labs

Launch genomic products without a genetics team

New high-margin SKUs from samples you already run — no wet-lab build, no bioinformatics hires, no model risk.

Buysnew revenue per existing sample · One.Age product line · clinician-ready reports

Women's health platforms

Own the hormonal-health category

Life-stage programmes — PCOS, perimenopause, menopause — built on hormonal intelligence none of your competitors can replicate from quizzes.

Buyscategory leadership · defensible personalisation · premium-tier pricing

Wellness & nutrition apps

Retention through personalisation that's real

Quiz-based plans churn. Plans grounded in a member's genome and bloodwork — with a retest loop — keep them subscribed.

Buyslower churn · higher LTV · a reason to retest every quarter

Fitness & performance

Sell programmes the genome can defend

Readiness, recovery and trainability signals turn coaching from opinion into evidence — and into a premium product tier.

Buyspremium tiers · athlete outcomes · coach credibility

Healthcare providers

Find risk before symptoms do

Continuous signal-tracking between visits — ranked priorities and explainable mechanisms clinicians can act on and defend.

Buyspre-symptomatic detection · preventive revenue line · member loyalty

Insurers & employers

See risk while it's still moving

Dynamic cohort stratification and outcome-driven One.Age+ programmes — engagement that shows up in claims and absenteeism.

Buysclaims-relevant stratification · measurable programme outcomes

09 — The One.Age line

One.Age — one engine,
ascending depth.

A product ladder built on the same intelligence layer. Partners start where their data starts, and climb as depth pays for itself.

One.Age | QuickLifestyle questionnaire RESULTS IN MINUTES · NO LABBiological age estimate — the hook that starts a member's health journey and books the first panel.WELLNESS APPS CORPORATE SCREENING
One.Age | SimpleRoutine blood markers RESULTS IN 24HBiological age + 6 organ-system ages from panels your lab already runs — a new SKU with zero new wet-lab work.DIAGNOSTIC LABS PROVIDERS
One.Age | PreventBlood + genome + lifestyle 115-MARKER PANELThe flagship: 10 system scores, ranked priorities with mechanism, personalised therapeutics and a 90-day retest loop.PROVIDERS · PLATFORMS PREMIUM MEMBER TIERS
One.Age | Advance+ Epigenetics + expression MOLECULAR-LEVEL CLOCKSGold standard — demonstrable expression-level change in ageing genes, bespoke supplements, personalised therapies.LONGEVITY CLINICS HNI PROGRAMMES

Signals API & white-label

Everything above is available as an API and as white-label report infrastructure — POST /v1/signals in, ranked explainable intelligence out. Annual One.Age+ programmes for corporates and insurers run on the same rails.

Get API access

10 — Scientific foundation

Built on biology.
Validated by data.

Every signal is mechanism-first: correlated to the hallmarks of ageing and traced to named molecular pathways, so a clinician — or a regulator — can follow the reasoning end to end.

3.5B+annotated, longitudinal datapoints from a proprietary Indian cohort
75+clinical, biochemical and molecular sources in the evidence metadatabase
115blood markers in the flagship panel, processed via NABL-accredited lab partners
4clock depths — system, organ, tissue, molecular — matched to available data

08 — Defensibility

A system that gets smarter with every sample.

Every partner adds multimodal, longitudinal, population-specific data. Every datapoint sharpens the clocks. Sharper clocks produce better outcomes; better outcomes bring more partners. The moat is not the model — it is the compounding cohort no one else is building.

MORE PARTNERSMORE DATASHARPER MODELSBETTER OUTCOMESMORE ADOPTION3.5B+ →DATAPOINTS

11 — Common questions

Genomic intelligence, answered.

Are polygenic risk scores accurate for Indian populations?
Not by default. Most PRS are trained on European-ancestry cohorts and lose meaningful accuracy on Indian genomes. Rewise normalises every score and ageing clock against a proprietary longitudinal Indian cohort — 3.5 billion+ annotated datapoints — restoring sensitivity and specificity for the populations our partners actually serve.
What is a continuous genomic intelligence layer?
The genome is read once and never changes; what it means for a person changes with every blood panel, every training block, every life stage. A continuous genomic intelligence layer re-reads the constant against the stream — scanning millions of datapoints and surfacing the few signals relevant right now, ranked by impact and traced to mechanism.
Is biological age the only output?
No. Biological age is one signal among many — for some members it's the headline; for an athlete the headline might be recovery capacity or a VO₂max ceiling gated by ferritin; for a women's-health programme, hormonal and methylation signals. The platform ranks what matters per person.
How do we integrate — and how fast?
Three routes: the Signals API for product teams, white-label report infrastructure for labs and clinics, and packaged One.Age / One.Age+ programmes for providers, corporates and insurers. The platform is data-agnostic: it ingests output from any accredited lab, wearable or EHR you already use.
How is member data handled?
Data is structured, harmonised and de-identified on ingestion. Partner data is never sold; any future research use happens only in de-identified form. Lab work runs through NABL-accredited partners.

Partner with Rewise

Build the precision-health product your members are waiting for.

Tell us what you're building. We'll show you the platform live — your use case, real signals, and the fastest route from your data to your first intelligence-powered release.

info@rewisehealth.comEmail
India · expanding GCC, SG, UKOperating regions

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